The amount of antibody produced by a person’s immune system can straight correlate with the variety of gene copies encoding that particular antibody. This phenomenon, the place the quantity of protein expressed is proportional to the variety of gene copies, is noticed in a number of immunoglobulin varieties. An easy instance is seen in people with various numbers of sure IgG gene copies; these with extra copies are inclined to exhibit greater ranges of the corresponding IgG antibody of their serum.
The sensible relevance of this relationship extends to diagnostics and immunogenetics. Figuring out antibodies exhibiting such a correlation might be precious in figuring out genetic predispositions to sure illnesses or immune deficiencies. Traditionally, understanding gene copy quantity variation and its affect on protein expression has been elementary in learning the genetic foundation of numerous phenotypic traits, together with immune responses.
